Understanding the effects of GLP-1s

Ozempic, Wegovy, Mounjaro, and other GLP-1 medications have become a major part of the weight loss conversation. As more people consider or use these medications, questions are growing around muscle loss, side effects, long-term sustainability, and what happens after the medication stops.

Research suggests that up to 40% of the weight loss while on GLP-1s may come from lean body mass, including muscle and bone. That matters at any age. But for older adults, it’s especially concerning. When you lose too much weight too quickly, it can accelerate muscle loss and increase the risk of falls, injuries, and even long-term disability.

Lean muscle mass: an important part of weight loss and longevity

Lean muscle mass is an essential component of the body, as it serves as an energy reserve and supports physical activity that requires mobility, strength, and balance. At GOLO, we prioritize preserving lean muscle mass because we recognize its importance and aim to help our users lose fat rather than muscle.

Many weight loss medications can appear to prioritize the drug over lifestyle and behavioral changes, such as strength training exercises and improving eating habits. As a result, these important changes may not be emphasized with weight loss medications as much as they should. When you don't consume the proper amount of nutrients for an extended period, your metabolic rate drops.

This can lead to your body utilizing muscle tissue for energy, resulting in muscle wasting. Essentially, it's similar to your body going into starvation mode.

The goal isn’t just to weigh less

It’s to be healthy, look and feel better, and live life to its fullest for years to come

GLP-1 medications do not address the underlying causes of weight gain or teach you how to keep the weight off long-term. They rely on turning off your body’s natural hunger signal, interrupting the gut-brain connection. Because these drugs suppress your appetite, they may prevent you from getting the essential nutrients your body needs and put you at risk for potential side effects. Worse, once the medication is stopped, many people regain the weight, creating long-term dependency.